賀古 眞MAKOTO KAKO

資格

• 日本肝臓学会指導医・専門医
• 日本消化器病学会指導医・専門医
• 日本内科学会認定内科医
• 神奈川県難病指定医

所属学会

• 日本内科学会
• 日本肝臓学会
• 日本消化器病学会
• 日本胆道学会

業績

【学会発表】

1. Kazuhiro Abe, Hiroshi Miyakwa, Kiyomitsu Miyachi, Makoto Kako and Hisashi Furue:　Anti-Liver / Kidney MicrosmeーⅠ-Positive Chronic Hepatitis C with Type Ⅰ Cryoglobulinemia Responding to Interferon.
   Internal Medicine 34(11):1114-1119,1995
2. Hiroshi Miyakawa, Kazuhiro Abe, Makoto Kako : So－Called 　“Autoimmune　Hepatitis Type Ⅱb” is not categorized in Autoimmune Hepatitis. A J G 1365,1995
3. Hiroshi Miyakawa, Kazuhiro Abe, Makoto Kako : Heterogeneity of
   Autoantigens to anti－liver/kidney microsome 1 (LKM1): analysis by western blotting.
   International Hepatology Communication 3:1-5, 1995
4. T. Aikawa, K. Kanai, M. Kako, T. Kawasaki, K. Hino, S. Iwabuchi, H.Tsubouchi, Y. Takehira, F. Tsuda, H. Okamoto, Y. Miyakawa and M. Mayumi: Interferon―α2a for chronic hepatitis B with e antigen or antibody: comparable antiviral effects on wild-type virus and precore mutant. Journal of Viral Hepatitis 2:243-250,1995
5. Koichi Kanai, Makoto Kako, Tatsuya Aikawa, Takashi Kumada, Tsunehisa Kawasaki, Terumasa Hatahara, Yuji Oka, Masashi Mizokami, Takahiro Sakai, Koichiro Iwata, Hiroaki Okamoto and Makoto Mayumi:
   Clearance of serum hepatitis C virus RNA after interferon therapy in relation to viral genotype. Liver 15:185-188,1995
6. K. Kanai, M. Kako, T. Aikawa, T. Kumada, T. Kawasaki, T. Hatahara, Y. Oka, M. Mizokami, T. Sakai, K. Iwata, H. Okamoto, M. Mayumi and S. Mishiro: HCV RNA monitoring for tailored regimens of interferon therapy in hepatitis C. Biomed & Pharmacother 49:65-67,1995
7. Koichi Kanai, Makoto Kako, Tatsuya Aikawa, Kunihiko Hino, Hirohito Tsubouchi, Yasunori Takehira, Shogo Iwabuchi, Tsunehisa Kawasaki, Fumio Tsuda, Hiroaki Okamoto, Yuzo Miyakawa and Makoto Mayumi: Core Promotor Mutations of Hepatitis B Virus for the Response to Interferon in e Antigen-positive Chronic Hepatitis B. AJG 91:2150-2156,1966
8. Makoto Kako, Koichi Kanai, Tatsuya Aikawa, Shogo Iwabuchi, Yasunori Takehira, Tsunehisa Kawasaki, Hirohito Tsubouchi, Kunihiko Hino, Fumio Tsuda, Hiroaki Okamoto, Yuzo Miyakawa, Makoto Mayumi: Response to Interferon-α2a in Patients with e Antigen-Negative Chronic Hepatitis B. J Clin Gastroenterol 25(2):440－445，1997
9. 賀古　眞：B型慢性肝炎のインターフェロン治療の進めかたと有効性　Medical Practice 14(11):1821－1824,1997
10. 金井　弘一、賀古　眞、相川　達也、日野　邦彦,　坪内　博仁、竹平　安則、　岩淵　省吾、河崎　恒久、津田　文男、岡本　宏明、真弓　忠：B型慢性肝炎に対するIFN24週間投与　肝臓39(2)62-67、1998
11. K. Kanai, M. Kako, T. Kumada, H. Tsubouchi, T. Aikawa, M. Kojima, H. Harada, T. Kawasaki, M. Nakajima, H. Okamoto and S. Mishiro: High－dose(9MU) long－term(60 weeks) alfa－interferon therapy for chronic hepatitis patients infected with HCV genotype 1b. Arch Virol 143:1545－1554,1998
12. K. Miyachi, H. Matsushima, R. W. Hankins, M. Hirakata, T. Mimori, H. Hosaka, Y. Amagasaki, H. Miyakawa, M. Kako, M. Shibata, Y. Onozuka and U.Ueno : A Novel Antibody Directed Against a Three―Dimentional Configuration of a 95- kDa Protein in Patients with Autoimmune Hepatic Diseases. Scand. J. Immunol 47:63-68,1998
13. Hiroshi Miyakawa, Naomi Kawaguchi, Kentaro Kikuchi, Hirotoshi Fujikawa, Eriko Kitazawa, Masanao Matsushita, Kazuhiro Abe, Makoto Kako: Combination assays for IgG class and IgM class anti-pyruvate dehydrogenase complex (PDC) －E2 by ELISA using recombinant autoantigen to diagnose primary biliary cirrhosis. Hepatology Research 12:140-150,1998
14. Hiroshi Miyakawa, Hiroshi matsushima, Yoichi Narita, Raleigh W. Hankins, Eriko Kitazawa, Hirotoshi Fujikawa, Kentaro Kikuchi, Masanao Matsushita, Kazuhiro Abe, Naomi Kawaguchi, Toshio Morizane, and Makoto Kako: Differences in antigenic sites, recognized by anti－liver－kidney microsome－1 (LKM－1) autoantibody, between HCV－positive and HCV－negative sera in Japanese patients. J Gastroenterol 33:529-535,1998
15. Hiroshi Miyakawa, Eriko Kitazawa, Kazuhiro Abe, Masanao Matsushita, Naomi Kawaguchi, Hirotoshi Fujikawa, Kentaro Kikuchi, Makoto Kako: Anti－liver－kidney microsome－1 autoantibody in HCV－positive sera reacts predominantly to conformational epitope, not to linear epitope. Hepatology Research 10:112-120,1998
16. Hiroshi Miyakawa, Naomi Kawaguchi, Kazuhiro Abe, Eriko Kitazawa, Kentaro Kikuchi, Hirotoshi Fujikawa, Masanao Matsushita, Makoto Kako: Serial changes of serum anti－M2 proteins in patients with primary biliary cirrhosis: a follow－up study by immunoblotting.
    Hepatology Research 13:143-152,1999
17. Hiroshi Miyakawa, Kazuhiro Abe, Eriko Kitazawa, Kentaro Kikuchi, Hirotoshi Fujikawa, Masanao Matsushita, Naomi Kawaguchi, and Makoto Kako: Detection of Anti-branched Chain2―Oxo Acid Dehydrogenase Complex ( BCOADC )－E2 Antibody in Primary Biliary Cirrhosis by ELISA using Recombinant Fusion Protein. Autoimmunity 30:11-20,1999

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